xarray
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yt is a tool for querying, analyzing and visualizing objects or regions of interest to identify emergent properties in data available in a variety of real-world research data formats. Initially developed for use by professional astronomers, yt can be applied in a variety of domains including astrophysics, seismology, nuclear engineering, molecular dynamics, and oceanography.
Shogun
The Shogun Machine Learning Toolbox is devoted to making machine learning tools available for free, to everyone. It provides efficient implementation of all standard ML algorithms.
PyTables
PyTables is an efficient method for storing and querying both numerical and textual data. PyTables provides seamless access to the convenient HDF5 library, a popular container for datasets that can grow to terabytes and beyond.